Basic Information
| LncRNA/CircRNA Name | GAS6-AS2 |
| Synonyms | NA |
| Region | GRCh38_13:113864168-113866833 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR , Western blot , in vitro knockdown etc. |
| Sample | melanoma tissues and skin tissues ,Human epidermal melanocyte HEMa-LP ,Human melanoma cell lines (A375, SK-MEL-2,and SK-MEL-5) |
| Expression Pattern | up-regulated |
| Function Description | GAS6-AS2 is significantly elevated in melanoma tissues and cells. Elevated expression of GAS6-AS2 is positively correlated with advanced stages and poor prognosis in melanoma.Ectopic expression of GAS6-AS2 promotes proliferation and inhibits apoptosis of melanoma cells. In contrast, knockdown of GAS6-AS2 inhibits proliferation and promotes apoptosis of melanoma cells.GAS6-AS2 promotes melanoma xenograft growth.GAS6-AS2 upregulates GAS6 expression, promotes GAS6 secretion, and activates AXL/AKT/ERK signals.The expression of GAS6 was positively correlated with that of GAS6-AS2 in melanoma tissues. In addition, deficiency of GAS6 reverses the biological roles of GAS6-AS2 overexpression in melanoma cell proliferation and apoptosis. |
| Pubmed ID | 31162889 |
| Year | 2019 |
| Title | Increased Expression of Long Noncoding RNA GAS6-AS2 Promotes Proliferation and Inhibits Apoptosis of Melanoma Cells via Upregulating GAS6 Expression |
External Links
| Links for GAS6-AS2 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |