Basic Information
| LncRNA/CircRNA Name | GAS6-AS2 |
| Synonyms | NA |
| Region | GRCh38_13:113864168-113866833 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RT-qPCR, RIP, luciferase reporter assay, western blotting |
| Sample | tumor tissues,breast epithelial cell line MCF-10A and four human BC cell lines (BT-474, SKBR3, MCF-7, and MDA-MB-231) |
| Expression Pattern | up-regulated |
| Function Description | GAS6-AS2 expression was high in BC tumors, manifesting a strong correlation with tumor size, lymph node metastasis, TNM stage, and shorter overall survival in patients with BC. A knockdown of GAS6-AS2 restricted BC cell proliferation, migration, and invasion in vitro and retarded tumor growth in vivo. With regard to its mechanism, GAS6-AS2 acted as a competing endogenous RNA that sponged microRNA-493 (miR-493), thereby increasing the expression of fucosyltransferase IV (FUT4). |
| Pubmed ID | 31839366 |
| Year | 2020 |
| Title | Long Noncoding RNA GAS6-AS2 Sponges microRNA-493, Thereby Enhancing the Malignant Characteristics of Breast Cancer Cells via Upregulation of FUT4 |
External Links
| Links for GAS6-AS2 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |