Basic Information
| LncRNA/CircRNA Name | GAS6-AS2 |
| Synonyms | Growth arrest-specific 6 antisense RNA 2 |
| Region | GRCh38_13:113864168-113866833 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, luciferase reporter analysis, Western blot |
| Sample | HCC tissues,HCC cell lines including Hep3B, HuH-7, Li-7 and CSQT-2, and normal liver cells HL-7702 |
| Expression Pattern | up-regulated |
| Function Description | GAS6-AS2 was up-regulated in HCC tissues and cells. GAS6-AS2 knockdown inhibited proliferation, migration, and invasion but promoted apoptosis. MiR-493-5p, a target of GAS6-AS2, was down-regulated in HCC tissues and cells. GAS6-AS2 knockdown suppressed proliferation, migration, and invasion but promoted apoptosis of HCC cells by impeding PI3K/AKT/FoxO3a signaling pathway through regulating the GAS6-AS2/miR-493-5p/OTUB1 axis. |
| Pubmed ID | 31933797 |
| Year | 2019 |
| Title | LncRNA GAS6-AS2 Facilitates Tumor Growth and Metastasis of Hepatocellular Carcinoma by Activating the PI3K/AKT/FoxO3a Signaling Pathway |
External Links
| Links for GAS6-AS2 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |