Basic Information
| LncRNA/CircRNA Name | GAS5-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:173863248-173863941 |
| Ensemble | ENSG00000270084 |
| Refseq | NR_037605 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR etc. |
| Sample | HCC surgical tissues |
| Expression Pattern | down-regulated |
| Function Description | GAS5-AS1 was down-regulated in HCC tissues .Expression of GAS5-AS1 was notably associated with differentiation, tumor-node-metastasis (TNM) stage (I??I vs III??V, P= 0.020) and glucose levels (< 6.2 vs??6.2, P= 0.047) in HCC patients. GAS5-AS1 expression had a relatively poor prognosis. Univariate and multivariate analysis elaborated that GAS5-AS1 was an independent prognostic factor for HCC patients. |
| Pubmed ID | 29660898 |
| Year | 2018 |
| Title | Down-regulation of long non-coding RNA GAS5-AS1 and its prognostic and diagnostic significance in hepatocellular carcinoma. |
External Links
| Links for GAS5-AS1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |