Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, in vitro knockdown etc. |
| Sample | colorectal cancer tissues, cell lines (SW480, SW620, RKO, HCT116, HT-29, LoVo and LS174T) |
| Expression Pattern | down-regulated |
| Function Description | GAS5 mRNA expression was observed to be markedly downregulated in human CRC tissues and cell lines. Functional assays demonstrated that overexpression of GAS5 inhibited cell proliferation and survival, and induced G0/G1 cell cycle arrest and apoptosis; however, knockdown of GAS5 expression enhanced cell proliferation, and reduced G0/G1 arrest and apoptosis. |
| Pubmed ID | 28521420 |
| Year | 2017 |
| Title | Long non-coding RNA GAS5 inhibits cell proliferation, induces G0/G1 arrest and apoptosis, and functions as a prognostic marker in colorectal cancer. |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |