Detail

Basic Information

LncRNA/CircRNA Name	GAS5
Synonyms	GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007
Region	GRCh38_1:173863900-173868882
Ensemble	ENSG00000234741
Refseq	NR_002578

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	colorectal cancer
ICD-0-3	C19.9
Methods	qPCR etc.
Sample	cell line (SW480), CRC tissues
Expression Pattern	up-regulated
Function Description	LncRNA GAS5 is upregulated while the miR-221 is downregulated in the tissues,plasma and exosomes of patients with CRC. The results of ROC showed that the expressions of both lncRNA GAS5 and miR-221 in the tissues, plasma and exosomes had diagnostic value in CRC. While the LncRNA GAS5 expression in tissues, plasma and exosomes were associated with the tumor node metastasis (TNM) stage,Dukes stage,lymph node metastasis (LNM),local recurrence rate and distant metastasis rate,the MiR-221 expression in tissues, plasma and exosomes were associated with tumor size, TNM stage, Dukes stage, LNM, local recurrence rate and distant metastasis rate.LncRNA GAS5 and miR-221 expression in tissues, plasma and exosomes were found to be independent prognostic factors for CRC. Following the overexpression of GAS5, the GAS5 expressions was up-regulated and miR-221 expression was down-regulated;the rate of cell proliferation,migration and invasion were decreased.
Pubmed ID	29630521
Year	2018
Title	Prognostic and predictive value of long non-coding RNA GAS5 and mircoRNA-221 in colorectal cancer and their effects on colorectal cancer cell proliferation, migration and invasion.

External Links

Links for GAS5	GenBank HGNC NONCODE
Links for colorectal cancer	OMIM COSMIC