Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Cisplatin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | NSCLC tissues, cell lines (H1650, H1299, H1975, A549 etc.) |
| Expression Pattern | down-regulated |
| Function Description | NSCLC tissues had a substantially lower expression of GAS5 than adjacent normal tissues. The NSCLC tissues from patients with progressive disease (PD) had even lower GAS5 expression. |
| Pubmed ID | 27338051 |
| Year | 2016 |
| Title | GAS5 modulated autophagy is a mechanism modulating cisplatin sensitivity in NSCLC cells. |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |