Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Dual luciferase reporter assay, MTT assay etc. |
| Sample | NSCLC tissues, cell lines (A549, H838, H157, HCC827) |
| Expression Pattern | down-regulated |
| Function Description | GAS5 was down-regulated in NSCLC tissues and cells and was negatively correlated with miR-23a expression.GAS5 directly interacted with miR-23a and reversely regulate its expression. miR-23a overexpression markedly promoted NSCLC cell proliferation and invasion, while GAS5 overexpression dramatically inhibited NSCLC cell proliferation, invasion and promoted apoptosis. |
| Pubmed ID | 28059053 |
| Year | 2017 |
| Title | Long noncoding RNA GAS5 suppresses tumorigenesis by inhibiting miR-23a 5 expression in non-small cell lung cancer. |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |