Basic Information
| LncRNA/CircRNA Name | AB073614 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot |
| Sample | SPCA1, PC-9, H1975, and normal human bronchial epithelial cell16HBE, NSCLC, adjacent tissues |
| Expression Pattern | up-regulated |
| Function Description | the AB073614 expression level in NSCLC samples was significantly higher. Moreover, after AB073614 was knocked down, invasion and migration of NSCLC cells were inhibited. And after AB073614 was overexpressed, invasion and migration of NSCLC cells were promoted. Also, mRNA and protein expression level of CDKN1A was upregulated via knockdown of AB073614, while mRNA and protein expression level of CDKN1A was downregulated via overexpression of AB073614. Besides, the expression of CDKN1A in NSCLC tissues was negatively correlated to the expression of AB073614. |
| Pubmed ID | 31298333 |
| Year | 2019 |
| Title | LncRNA AB073614 promotes tumor migration and invasion by repressing CDKN1A in non small cell lung cancer |
External Links
| Links for AB073614 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |