Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR etc. |
| Sample | HCC tissues |
| Expression Pattern | down-regulated |
| Function Description | The expression level of GAS5 was reduced in HCC in comparison to normal matched tissues. It is also proved that GAS5 expression was to be associated with HCC tumor size, lymphnode metastasis and clinical stage. In addition, the Kaplan-Meier survival curves revealed that low GAS5 expression was associated with poor prognosis in HCC patients. GAS5 expression was an independent prognostic marker of overall HCC patient survival in a multivariate analysis. |
| Pubmed ID | 25120813 |
| Year | 2014 |
| Title | Down-regulation of long non-coding RNA GAS5 is associated with the prognosis of hepatocellular carcinoma. |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |