Basic Information
| LncRNA/CircRNA Name | AGAP2-AS1 |
| Synonyms | AGAP2-AS1, PUNISHER |
| Region | GRCh38_12:57726271-57728356 |
| Ensemble | ENSG00000255737 |
| Refseq | NR_027032 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi, Western blot, RIP, ChIP, Luciferase reporter assay, Cell proliferation assay, Cell migration and invasion assay etc. |
| Sample | gastric cancer tissues, cell lines (BGC823, SGC7901, AGS, MGC803, and MKN45) |
| Expression Pattern | up-regulated |
| Function Description | AGAP2-AS1 was highly expressed in the GC tissues and cell lines. Knockdown of AGAP2-AS1 significantly inhibited GC cell proliferation, migration, and invasion in vitro and tumor growth in vivo. AGAP2-AS1 overexpression promoted cell growth and invasion. In addition, the transcription factor SP1 activated AGAP2-AS1 expression in the GC cells. AGAP2-AS1 functions as an oncogenic lncRNA by interacting with LSD1 and EZH2 and suppressing CDKN1A (P21) and E-cadherin transcription. |
| Pubmed ID | 28209205 |
| Year | 2017 |
| Title | Long noncoding AGAP2-AS1 is activated by SP1 and promotes cell proliferation and invasion in gastric cancer. |
External Links
| Links for AGAP2-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |