Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | ovarian cancer tissue, cell lines (SKOV3, OVCAR-3, A2780 and 3AO,IOSE25) |
| Expression Pattern | down-regulated |
| Function Description | Decrease in lncRNA GAS5 expression resulted in increased cell proliferation and colony formation and reduced ovarian cancer cell apoptosis.In contrast, exogenous overexpression of lncRNA GAS5 in ovarian cancer cells inhibited proliferation, colony formation and apoptosis in ovarian cancer cells.the role of lncRNA GAS5 in ovarian cancer was associated with inflammasome formation and pyroptosis. |
| Pubmed ID | 29229673 |
| Year | 2017 |
| Title | LncRNA GAS5 suppresses ovarian cancer by inducing inflammasome formation. |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |