Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR etc. |
| Sample | lung cancer tissues |
| Expression Pattern | differential expression |
| Function Description | In current study, we investigated the possible association between susceptibility of lung cancer and GAS5 rs145204276, which showed contradictory roles in carcinogenesis of colorectal cancer and hepatocellular carcinoma. Taken together, our findings provided strong evidence for the hypothesis that GAS5 rs145204276 were significantly associated with the susceptibility of lung cancer, and GAS5 functions as a tumor suppressor in carcinogenesis of lung cancer. In summary, we demonstrated that SNP rs145204276 of GAS5 was associated with decreased risk of lung cancer in the Chinese populations. These findings should be verified by larger, well-designed epidemiologic and functional studies. |
| Pubmed ID | 29207621 |
| Year | 2017 |
| Title | Genetic variation of lncRNA GAS5 contributes to the development of lung cancer. |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |