Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | 2-O-Methylmagnolol | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, RNAi, Western blot, Flow cytometry assay etc. |
| Sample | skin cancer tissues, cell line (A431) |
| Expression Pattern | down-regulated |
| Function Description | The level of GAS5 was increased in MM1-treated cells, and inhibition of lncRNA GAS5 inhibited MM1-induced apoptosis. Conversely, overexpression of lncRNA GAS5 inhibited cell proliferation and promoted cell apoptosis in skin cancer cells. The expression of lncRNA GAS5 in the skin cancer tissues was found to be lower than that in the adjacent normal tissues in a majority of patients. |
| Pubmed ID | 28252643 |
| Year | 2017 |
| Title | 2-O-Methylmagnolol upregulates the long non-coding RNA, GAS5, and enhances apoptosis in skin cancer cells. |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for squamous cell carcinoma | OMIM COSMIC |