Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | Luciferase reporter assay, qPCR, RIP |
| Sample | esophageal squamous cell carcinoma, cell lines (EC109,KYSE150,KYSE450,HET-1A) |
| Expression Pattern | down-regulated |
| Function Description | miR-196a could suppress the expression of lncRNA growth arrest-specific 5(GAS5). GAS5 is frequently down-regulated in 86 paired human ESCC tissues. GAS5 could inhibit the growth of ESCC cells. miR-196a could bind to GAS5.GAS5 functions as a tumor suppressor gene in ESCC and is regulated by miR-196a involved in RISC. |
| Pubmed ID | 29170131 |
| Year | 2017 |
| Title | Negative regulation of lncRNA GAS5 by miR-196a inhibits esophageal squamous cell carcinoma growth |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |