Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Lentiviral infection, Western blot, Luciferase reporter assay, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | cell lines (MCF-7, T47D, MDA-MB-231) |
| Expression Pattern | down-regulated |
| Function Description | Here, Gas5 is found to be downregulated in glioma specimens and U87 and U251 glioma cell lines. We showed that the introduction of Gas5 by plasmid transfection increased the expression of tumor suppressor Bcl-2-modifying factor (bmf) and Plexin C1 via directly targeting and reducing the expression of miR-222. Downregulated expression of miR-222 inhibited U87 and U251 cell proliferation and promoted the apoptosis by upregulating bmf. |
| Pubmed ID | 26370254 |
| Year | 2015 |
| Title | Gas5 Exerts Tumor-suppressive Functions in Human Glioma Cells by Targeting miR-222. |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |