Basic Information
| LncRNA/CircRNA Name | Gas5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase reporter assay, Western blot |
| Sample | papillary thyroid carcinoma tissues, cell lines ( BHP5-16, TPC, K1 and BHP2-7, Nthy-ori 3-1) |
| Expression Pattern | down-regulated |
| Function Description | Over-expression of Gas5 remarkably suppressed PTC cells proliferation in vitro and inhibited the growth of tumor cells in vivo likewise. Gas5 was identified as a target of miR-222-3p which was aberrantly high in PTC cells.Enhanced expression of miR-222-3p promoted the proliferation of PTC cells while knocking down miR-222-3p could inhibit it. The advanced effects of miR-222-3p on the proliferation of PTC cells could be partly reversed by the upregulation of Gas5 expression.Gas5 increased the protein level of the PTEN,one of miR-222-3p's targets, which further activated PTEN/AKT pathway. |
| Pubmed ID | 29423063 |
| Year | 2017 |
| Title | LncRNA Gas5 acts as a ceRNA to regulate PTEN expression by sponging miR-222-3p in papillary thyroid carcinoma. |
External Links
| Links for Gas5 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |