Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | qRT-PCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | EC cell lines (ECA109, TE-1, TE-3 and EC9706), esophageal epithelia cell line (SHEE) |
| Expression Pattern | up-regulated |
| Function Description | GAS5 expression was increased in EC cells (ECA109, TE-1, TE3 and EC9706) compared to SHEE cells.Knockdown of GAS5 decreased cell viability,migration,invasion,and induced apoptosis in EC9706 cells.Moreover,miR-301a was directly sponged to GAS5,and miR-301a suppression obviously alleviated the pro-tumor effects of GAS5.Furthermore,miR-301a positively regulated CXCR4 expression,and overexpression of CXCR4 induced apoptosis and abolished the promoting effect of miR-301a inhibition on cell viability,migration and invasion.Besides,miR-301a blocked Wnt/B-catenin and NF-kB signal pathways by regulation of CXCR4. |
| Pubmed ID | 29386089 |
| Year | 2018 |
| Title | Long non-coding RNA GAS5 promotes proliferation, migration and invasion by regulation of miR-301a in esophageal cancer. |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for esophageal cancer | OMIM COSMIC |