Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | multiple myeloma |
| ICD-0-3 | C42.1 |
| Methods | qPCR etc. |
| Sample | blood (plasma) |
| Expression Pattern | down-regulated |
| Function Description | GAS5 was significantly lower in the patients with MM and slightly higher in the CLL group but in the latter case the difference was not significant. Downregulation of GAS5 is expected to inhibit apoptosis and allow the cells to maintain a more rapid cell cycle. |
| Pubmed ID | 24583225 |
| Year | 2014 |
| Title | Investigation of circulating lncRNAs in B-cell neoplasms. |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for multiple myeloma | OMIM COSMIC |