Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Luciferase reporter assay, other |
| Sample | ovarian cancer tissues and cell lines (SKOV3, OVCAR-3, A2780 and HO8910) |
| Expression Pattern | down-regulated |
| Function Description | Lower GAS5 expression and higher miR-196a-5p expression were associated with larger tumor size (?? cm) and more advanced FIGO stage (III-IV) of OA patients. Transfection of si-GAS5, miR-196a-5p mimic or si-HOXA5 conferred OA cells with stronger viability, faster proliferation and smaller percentage of apoptosis (P < 0.05). After injecting mice models with si-GAS5, miR-196a-5p mimic or si-HOXA5, a larger tumor size was also observed within the rats (P < 0.05). GAS5 was indicated to directly target miR-196a-5p and modify its expression, and the targeted relationship also seemed to exist between miR-196a-5p and HOXA5. The HOXA5 was found to reverse the effects imposed by miR-196a-5p on viability, proliferation and apoptosis of OA cells. |
| Pubmed ID | 30201235 |
| Year | 2018 |
| Title | Lowly-expressed lncRNA GAS5 Facilitates Progression of Ovarian Cancer Through Targeting miR-196-5p and Thereby Regulating HOXA5 |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |