Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | NA |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR |
| Sample | glioma tissue, cell lines(U251, U87) |
| Expression Pattern | down-regulated |
| Function Description | we demonstrated that overexpression of GAS5 inhibits malignant phenotypes in glioma cells, including proliferation, migration, and invasion, whereas GAS5 knockdown enhances these phenotypes. Downregulation of GAS5 and upregulation of miR-18a-5p were observed in glioma tissue microarrays relative to normal brain tissue by ISH. |
| Pubmed ID | 30078184 |
| Year | 2018 |
| Title | Long Noncoding RNA GAS5 Regulates the Proliferation, Migration, and Invasion of Glioma Cells by Negatively Regulating miR-18a-5p. |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |