Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | NA |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | endometrial cancer |
| ICD-0-3 | NA |
| Methods | RT-PCR, Western blotting etc. |
| Sample | human endometrial carcinoma cell lines(HEC1-B, HEC1-A and Ishikawa) |
| Expression Pattern | down-regulated |
| Function Description | GAS5 was under-expressed in the endometrial carcinoma tissue specimens, especially these samples with type 2 diabetes mellitus. Besides, the aberrant under-expression of GAS5 was correlated with the advanced tumor stage as well as poor prognosis outcome.GAS5 was decreased in the cells exposed to the high glucose. Enforced GAS5 expression repressed the tumor phenotype of endometrial carcinoma cells, including proliferation and invasion. GAS5 functioned as a sponge for miR-222-3p, abrogating its ability of inhibiting p27 protein expression. |
| Pubmed ID | 31105847 |
| Year | 2019 |
| Title | Long Noncoding RNA GAS5 Impairs the Proliferation and Invasion of Endometrial Carcinoma Induced by High Glucose via Targeting miR-222-3p/p27 |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for endometrial cancer | OMIM COSMIC |