Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | NA |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | glioma and normal brain tissues, glioma cells (U251, U87), human normal glial cell line HEB |
| Expression Pattern | down-regulated |
| Function Description | The expression of lncRNA GAS5 was significantly decreased in glioma cell lines compared with normal glial cells.In addition, overexpression of lncRNA GAS5 inhibited the proliferation, migration and invasion of glioma cell lines, and promoted cell apoptosis as demonstrated by the increased activity of Caspase 3/7.lncRNA GAS5 can effectively inhibit the proliferation, migration and invasion of glioma cells and promote cell apoptosis through targeting GSTM3 expression. |
| Pubmed ID | 31172354 |
| Year | 2019 |
| Title | LncRNA GAS5 Regulates the Proliferation, Migration, Invasion and Apoptosis of Brain Glioma Cells Through Targeting GSTM3 Expression. The Effect of LncRNA GAS5 on Glioma Cells |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |