Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | growth-stasis specific transcript 5 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Paclitaxel,Cisplatin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | Dual luciferase reporter gene experiment, RIP, RT-qPCR, Western blotting |
| Sample | TNBC cell lines MDA-MB-231 and BT549,breast cancer tissue |
| Expression Pattern | down-regulated |
| Function Description | the expression of lncRNA GAS5 was significantly downregulated in cells treated with paclitaxel (PTX) or cisplatin (CIS). Furthermore, TNBC cells with low expression of lncRNA GAS5 had a lower percentage of apoptosis under stress conditions, especially in serum-free medium. More interestingly, the expression level of lncRNA GAS5 in TNBC patients was associated with tumor resistance to PTX and CIS.lncRNA GAS5 could induce apoptosis in TNBC cells by targeting miR-378a-5p/SUFU signaling. |
| Pubmed ID | 31692053 |
| Year | 2020 |
| Title | lncRNA GAS5-promoted Apoptosis in Triple-Negative Breast Cancer by Targeting miR-378a-5p/SUFU Signaling |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |