Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | growth arrest specific 5 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | RT-qPCR, Western blot analysis, Dual luciferase reporter gene assay |
| Sample | ESCC tissues,ESCC cell TE-1 |
| Expression Pattern | down-regulated |
| Function Description | underexpressed GAS5 and RECK, and overexpressed miR-21 in ESCC. GAS5 elevation and miR-21 inhibition reduced viability and the colony formation ability, and enhanced the apoptosis of ESCC cells under radiation.GAS5 elevation up-regulates RECK expression by down-regulating miR-21 to increase ESCC cell apoptosis after radiation therapy, thus enhancing cell radio-sensitivity. |
| Pubmed ID | 31866421 |
| Year | 2020 |
| Title | Elevation of Long Non-Coding RNA GAS5 and Knockdown of microRNA-21 Up-Regulate RECK Expression to Enhance Esophageal Squamous Cell Carcinoma Cell Radio-Sensitivity After Radiotherapy |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |