Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | growth arrest-specific 5 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot assay |
| Sample | glioma U251 and A172 cell lines |
| Expression Pattern | down-regulated |
| Function Description | GAS5 inhibited proliferation and motile behaviors, and fortified apoptosis.GAS5 negatively modulated Sirt1 via miR-10b. Moreover, Sirt1 negatively modulated PTEN and positively mediated the abovementioned regulators. GAS5 represses the process of glioma cells by decreasing miR-10b, which as accompanied by Sirt1 silence-induced inactivation of PTEN/PI3K/AKT and MEK/ERK cascades. |
| Pubmed ID | 31889362 |
| Year | 2019 |
| Title | Long Noncoding RNA-GAS5 Attenuates Progression of Glioma by Eliminating microRNA-10b and Sirtuin 1 in U251 and A172 Cells |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |