Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | Growth Arrest-Specific 5 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blotting, Dual Luciferase Report |
| Sample | gastric cancer tissue,gastric cancer cell lines MKN45, SGC-7901, and BGC-823 and normal human gastric epithelium cell line GES-1 |
| Expression Pattern | down-regulated |
| Function Description | GAS5 was low expression and miR-21 was high expression in gastric cancer tissues and cells. GAS5 overexpression reduced the proliferation, migration, and invasion of gastric cancer cells and increased the apoptosis of gastric cancer cells. The growth rate of GAS5 group slowed down and the volume of tumor decreased. miR-21 is a GAS5 target and GAS5 inhibits the proliferation of gastric cancer cells by targeting miR-21. |
| Pubmed ID | 31910411 |
| Year | 2020 |
| Title | The Long Noncoding RNA, Growth Arrest-Specific 5, Suppresses Gastric Cancer by Downregulating miR-21 Expression |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |