Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | NA |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qRT-qPCR, Western blot |
| Sample | HCC tissues,cell lines |
| Expression Pattern | down-regulated |
| Function Description | GAS5 was downregulated in HCC cell lines and tumor tissues. Knockdown of GAS5 enhanced HCC cell proliferation in?vitro and in?vivo and increased HCC cell resistance to doxorubicin. GAS5 acted as a sponge for miR-21 silencing and consequently led to the elevation of PTEN expression. |
| Pubmed ID | 31705194 |
| Year | 2019 |
| Title | Downregulation of?LncRNA GAS5 promotes liver cancer proliferation and?drug resistance by?decreasing PTEN expression |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |