Basic Information
| LncRNA/CircRNA Name | GAPLINC |
| Synonyms | GAPLINC, LINC01540 |
| Region | GRCh38_18:3466250-3478978 |
| Ensemble | ENSG00000266835 |
| Refseq | NR_110429 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Microarray, ISH etc. |
| Sample | gastric cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | GAPLINC is a 924-bp-long lncRNA that is highly expressed in gastric cancer tissues. GAPLINC suppression and with gene expression profiling in gastric cancer cells revealed alterations in cell migration pathways, with CD44 expression the most highly correlated. Manipulating GAPLINC expression altered CD44 mRNA abundance and the effetcs of GAPLINC on cell migration and proliferation were neutralized by suppressing CD44 expression. |
| Pubmed ID | 25277524 |
| Year | 2014 |
| Title | Long Noncoding RNA GAPLINC Regulates CD44-Dependent Cell Invasiveness and Associates with Poor Prognosis of Gastric Cancer. |
External Links
| Links for GAPLINC | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |