Basic Information
| LncRNA/CircRNA Name | GAPLINC |
| Synonyms | NA |
| Region | GRCh38_18:3466250-3478978 |
| Ensemble | ENSG00000266835 |
| Refseq | NR_110429 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | gastric cancer tissues, cell lines (KATO III, HGC-27, and SNU-1) |
| Expression Pattern | up-regulated |
| Function Description | The lncRNA GAPLINC expression was upregulated and positively correlated with MAPK1 expression in gastric cancer tissues and cells. Additionally, lncRNA GAPLINC promoted the expression of MAPK1 and the enhancement of GC cell proliferation and cell cycle progression by LncRNA GAPLINC was dependent on MAPK1 in vitro and in vivo. Consequently, we found that miR-378 expression was inversely correlated with GAPLINC expression in GC tissues and cells. miR-378 could directly bind to GAPLINC and decreased GAPLINC expression, thus reducing MAPK1 expression. Furthermore, overexpression of miR-378 inhibited MAPK1 expression, cell proliferation, and cell cycle progression of gastric cancer cells, while these effects were abrogated by upregulating lncRNA GAPLINC expression. |
| Pubmed ID | 29785127 |
| Year | 2018 |
| Title | Long Noncoding RNA GAPLINC Promotes Gastric Cancer Cell Proliferation by Acting as a Molecular Sponge of miR-378 to Modulate MAPK1 Expression |
External Links
| Links for GAPLINC | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |