Basic Information
| LncRNA/CircRNA Name | GALNT5 uaRNA |
| Synonyms | NA |
| Region | GRCh38_2:157257598-157314211 |
| Ensemble | ENSG00000136542 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Microarray, RIP etc. |
| Sample | gastric cancer tissues??cell lines (MGC-803, SGC-7901 and AGS) |
| Expression Pattern | up-regulated |
| Function Description | We identified an lncRNA (GALNT5 uaRNA, UTR-associated RNA) that is derived from the 3'-UTR of GALNT5. This lncRNA was transcribed independently of the coding region of GALNT5 and was determined to be markedly upregulated in human gastric carcinoma relative to their corresponding normal gastric tissues by quantitative RT-PCR (qRT-PCR) analysis of tissues from 122 gastric carcinoma patients. The expression of GALNT5 uaRNA was significantly correlated with the TNM stage and with lymph node metastasis. Further results demonstrated that GALNT5 uaRNA facilitated the proliferation and migration of gastric cancer cells in vitro and promoted tumor growth in a mouse model of human gastric cancer. Our results also indicated that GALNT5 uaRNA might function in gastric cancer by binding with HSP90. |
| Pubmed ID | 29743591 |
| Year | 2018 |
| Title | GALNT5 uaRNA promotes gastric cancer progression through its interaction with HSP90. |
External Links
| Links for GALNT5 uaRNA | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |