Basic Information
| LncRNA/CircRNA Name | GACAT3 |
| Synonyms | GACAT3, LINC01458, lncRNA-AC130711 |
| Region | GRCh38_2:16050427-16085801 |
| Ensemble | ENSG00000236289 |
| Refseq | NR_126559 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Luciferase reporter assay, Western blot |
| Sample | cell lines (BGC-823,SGC-7901, MKN-45, AGS, 293T,GES-1) |
| Expression Pattern | up-regulated |
| Function Description | GACAT3 showed a higher expression in GC tissues and cell lines. Increased GACAT3 level was significantly associated with a shorter overall survival of patients with GC.knockdown of GACAT3 significantly inhibited proliferation, colony formation, migration, and invasion of GC cells in vitro. Moreover, underexpression of GACAT3 decreased tumorigenesis in vivo.GACAT3 directly binds to microRNA-497 (miR-497), and GACAT3 expression was inversely correlated with miR-497 expression. |
| Pubmed ID | 29091858 |
| Year | 2017 |
| Title | LncRNA GACAT3 promotes gastric cancer progression by negatively regulating miR-497 expression. |
External Links
| Links for GACAT3 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |