Basic Information
| LncRNA/CircRNA Name | GACAT3 |
| Synonyms | NA |
| Region | GRCh38_2:16050427-16085801 |
| Ensemble | ENSG00000236289 |
| Refseq | NR_126559 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | Western blot etc |
| Sample | HCC and adjacent normal tissues, cell line (QSG-7701, HepG2, HCCLM3, SK-Hep-1 and SMMC-7721) |
| Expression Pattern | up-regulated |
| Function Description | GACAT3 was silenced in the cells. Cell proliferation, apoptosis and migration were determined by MTT assay, flow cytometric analysis and transwell assay, respectively. It was demonstrated that GACAT3 was upregulated in liver cancer tissues. The inhibition of GACAT3 decreased the ability of hepatoma cells to proliferate and migrate, and increased apoptosis of the cells. |
| Pubmed ID | 32266036 |
| Year | 2020 |
| Title | Long Non-Coding RNA GACAT3 Promotes Liver Cancer Progression by Regulating the Proliferation, Apoptosis and Migration of Tumor Cells |
External Links
| Links for GACAT3 | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |