Basic Information
| LncRNA/CircRNA Name | FTX |
| Synonyms | FTX, LINC00182, MIR374AHG, NCRNA00182 |
| Region | GRCh38_X:73946555-74293574 |
| Ensemble | ENSG00000230590 |
| Refseq | NR_028379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay, MTT assay etc. |
| Sample | HCC tissues, cell lines (HepG2, Hep3B, Huh7, SMMC-7721 and Bel-7402) |
| Expression Pattern | up-regulated |
| Function Description | The results showed that the expression of lncRNA Ftx and miR-545 in HCC tissues were significantly higher than that in the non-tumor tissues and correlated with each other. Further results confirmed that lncRNA Ftx and miR-545 were upregulated in a panel of HCC cell lines compared with that in non-transformed LO2 hepatic cell line. LncRNA Ftx and miR-545functions to enhance proliferation, tumorigenicity and cell cycle progression of HCC cells. |
| Pubmed ID | 26992218 |
| Year | 2016 |
| Title | Ftx non coding RNA-derived miR-545 promotes cell proliferation by targeting RIG-I in hepatocellular carcinoma. |
External Links
| Links for FTX | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |