Basic Information
| LncRNA/CircRNA Name | FTX |
| Synonyms | FTX, LINC00182, MIR374AHG, NCRNA00182 |
| Region | GRCh38_X:73946555-74293574 |
| Ensemble | ENSG00000230590 |
| Refseq | NR_028379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | uveal melanoma |
| ICD-0-3 | C69.9 |
| Methods | qPCR, RNAi, RNA-FISH, Cell migration and invasion assay etc. |
| Sample | cell lines (HDF, MUM2B, OCM1, OCM1A, OM431, SP6.5, and 293T) |
| Expression Pattern | down-regulated |
| Function Description | Real-time PCR results showed that JPX expression was extremely weak in UM cells, whereas JPX expression was significantly increased in CANT1-expressing cells. Similarly, after CANT1 overexpression, FTX expression was markedly enhanced compared with that in control UM cells. |
| Pubmed ID | 28330694 |
| Year | 2017 |
| Title | CANT1 lncRNA Triggers Efficient Therapeutic Efficacy by Correcting Aberrant lncing Cascade in Malignant Uveal Melanoma. |
External Links
| Links for FTX | GenBank HGNC NONCODE |
| Links for uveal melanoma | OMIM COSMIC |