Basic Information
| LncRNA/CircRNA Name | FTX |
| Synonyms | NA |
| Region | GRCh38_X:73946555-74293574 |
| Ensemble | ENSG00000230590 |
| Refseq | NR_028379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, RIP etc. |
| Sample | cell line (H1650, H1975, A549 and H1299) |
| Expression Pattern | up-regulated |
| Function Description | RT-qPCR showed that FTX expression was up-regulated in LUAD cell lines. Loss-of-function assay indicated that FTX accelerated cell proliferation, migration and invasion, while inhibited cell apoptosis in LUAD. Besides, miR-335-5p, lowly expressed in LUAD cells, was discovered to be sponged by FTX. Subsequently, NUCB2 was identified as a target gene of miR-335-5p. Additionally, it was confirmed that NUCB2 functioned as an oncogene in LUAD. |
| Pubmed ID | 32226311 |
| Year | 2020 |
| Title | FTX Contributes to Cell Proliferation and Migration in Lung Adenocarcinoma via Targeting miR-335-5p/NUCB2 Axis |
External Links
| Links for FTX | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |