Basic Information
| LncRNA/CircRNA Name | FTX |
| Synonyms | NA |
| Region | GRCh38_X:73946555-74293574 |
| Ensemble | ENSG00000230590 |
| Refseq | NR_028379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot etc |
| Sample | GC tissue, cell lines(AGS, MGC-803, SGC7019, and NCI-N87) |
| Expression Pattern | up-regulated |
| Function Description | We found that the expression of FTX in tumor tissues of 71 GC patients was higher than that in paracancerous tissues, and the prognosis of patients with high FTX was poor. The expression of FTX in gastric cancer cells was higher than that in normal human gastric epithelial cells (GES-1). Transferring overexpression plasmid of FTX into gastric cancer cells (MGC-803 and SGC-7901) promoted cell proliferation and the ratio of cells in G0-G1 phase was decreased. Transferring si-FTX to MGC-803 and SGC-7901 led to opposite results. |
| Pubmed ID | 32271421 |
| Year | 2020 |
| Title | Long Non-Coding RNA FTX Promotes Gastric Cancer Progression by Targeting miR-215 |
External Links
| Links for FTX | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |