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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	hepatocellular carcinoma
ICD-0-3	C22.0
Methods	qPCR, Western blot, in vitro knockdown, RNAi
Sample	hepatocellular carcinoma tissues, cell lines (Huh7, SMMC-7721 and Bel-7402)
Expression Pattern	up-regulated
Function Description	Ftx was upregulated in human HCC tissues and cell lines and, notably, was associated with aggressive clinicopathological features. lncRNA Ftx overexpression promoted the proliferation, invasion and migration of HCC cells, whereas lncRNA Ftx knockdown resulted in the opposite effects. Furthermore, lncRNA Ftx affected the activity and expression of key enzymes in carbohydrate metabolism, suggesting that lncRNA Ftx may be involved in aerobic glycolysis in HCC. The measurement of glucose consumption, lactate production and glucose transporter expression further supported this assumption. Mechanistically, peroxisome proliferator-activated receptor ? (PPAR?) expression in human HCC tissues and cell lines was positively correlated with lncRNA Ftx. Inhibiting PPAR? in Huh7 cells partially abrogated the alterations in glucose uptake, lactate production and relative glycolytic enzyme expression induced by lncRNA Ftx; similarly, PPAR? activation in Bel-7402 cells partially rescued the lncRNA Ftx-mediated alterations.
Pubmed ID	29845188
Year	2018
Title	lncRNA Ftx Promotes Aerobic Glycolysis and Tumor Progression Through the PPAR? Pathway in Hepatocellular Carcinoma

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