Basic Information
| LncRNA/CircRNA Name | AFAP1-AS1 |
| Synonyms | AFAP1-AS1, AFAP1-AS, AFAP1AS, LOC84740 |
| Region | GRCh38_4:7754090-7778928 |
| Ensemble | ENSG00000272620 |
| Refseq | NR_026892 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, ChIP, RIP, Western blot, etc. |
| Sample | Cell lines (LOVO, SW1116, SW480, HCT116, SW620, HT29). 80 colorectal carcinoma tissues, 10 normal colon tissues. |
| Expression Pattern | up-regulated |
| Function Description | Our findings indicate that AFAP1-AS1 is an oncogenic lncRNA that promotes tumor progression and may be a novel prognostic factor in colorectal cancer. Targeting AFAP1-AS1 might be a potential therapeutic strategy for colorectal cancer treatment.Kaplan-Meier survival analysis revealed a statistically significant worse prognosis for colorectal cancer patients with high AFAP1-AS1 mRNA levels compared with those with low. |
| Pubmed ID | 29888110 |
| Year | 2018 |
| Title | Long noncoding RNA AFAP1-AS1 facilitates tumor growth through enhancer of zeste homolog 2 in colorectal cancer. |
External Links
| Links for AFAP1-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |