Basic Information
| LncRNA/CircRNA Name | FTH1P3 |
| Synonyms | FTH1P3, FTHL3, FTHL3P |
| Region | GRCh38_2:27392784-27393367 |
| Ensemble | ENSG00000213453 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qPCR, Cell transfection, Western blot, Luciferase reporter assay, RNA pull-down assay etc. |
| Sample | OSCC tissues, cell lines (SCC1, SCC25, TU183, HSU3, FADU, OEC-M1, SNU1041 etc.) |
| Expression Pattern | up-regulated |
| Function Description | FTH1P3 was over-expressed in OSCC and decreased the survival rate of OSCC patients.Ectopic expression of FTH1P3 facilitates cell proliferation and colony formation in OSCC cells.Moreover, FTH1P3 acted as a ceRNA, effectively becoming sponge for miR-224-5p and thereby modulating the expression of fizzled 5. Importantly, expression analysis revealed that both FTH1P3 and fizzled 5 were up-regulated in OSCC cell lines and tissues, and over-expression of fizzled 5 also functioned as an oncogene in OSCC cells. |
| Pubmed ID | 28093311 |
| Year | 2017 |
| Title | Long non-coding RNA FTH1P3 facilitates oral squamous cell carcinoma progression by acting as a molecular sponge of miR-224-5p to modulate fizzled 5 expression. |
External Links
| Links for FTH1P3 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |