Basic Information
| LncRNA/CircRNA Name | FTH1P3 |
| Synonyms | FTH1P3, FTHL3, FTHL3P |
| Region | GRCh38_2:27392784-27393367 |
| Ensemble | ENSG00000213453 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | laryngeal squamous cell cancer |
| ICD-0-3 | C32.3 |
| Methods | qRT-PCR, in vitro knockdown etc. |
| Sample | LSCC tissues and adjacent non-neoplastic tissues, human LSCC cell lines (Hep-2 and TU212) |
| Expression Pattern | up-regulated |
| Function Description | FTH1P3 expression was significantly up-regulated in LSCC tissues than that in non-neoplastic tissues. High FTH1P3 expression was positively correlated with the poor differentiation, high T classification, positive lymph node metastasis, and advanced clinical stage. High levels of FTH1P3 predicted a poor prognosis in LSCC patients. Moreover, elevated expression of FTH1P3 was found to increase LSCC cell proliferation, migration and invasion, and to inhibit cell apoptosis, Conversely, knockdown of FTH1P3 suppressed LSCC cell proliferation, migration and invasion, and induced cell apoptosis.In addition, overexpression of FTH1P3 resulted in an increase in cells in S phase and a decrease in cells in G0/G1 phase, whereas inhibition of FTH1P3 did the opposite effects. |
| Pubmed ID | 31142627 |
| Year | 2019 |
| Title | Increased Expression of lncRNA FTH1P3 Predicts a Poor Prognosis and Promotes Aggressive Phenotypes of Laryngeal Squamous Cell Carcinoma |
External Links
| Links for FTH1P3 | GenBank HGNC NONCODE |
| Links for laryngeal squamous cell cancer | OMIM COSMIC |