Basic Information
| LncRNA/CircRNA Name | FRMD6-AS2 |
| Synonyms | NA |
| Region | GRCh38_14:51454512-51599952 |
| Ensemble | ENSG00000258537 |
| Refseq | NR_047477 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | uterine corpus endometrial cancer |
| ICD-0-3 | NA |
| Methods | Western blot, qPCR |
| Sample | UCEC samples,UCEC cell lines COLO-684, HEC-108 and Ishikawa and uterus endometrium cells KC02-44D |
| Expression Pattern | down-regulated |
| Function Description | FRMD6-AS2 played a suppressive role in tumor growth, migration and invasion via activation of Hippo signaling pathway including FRMD6. Moreover, we also demonstrated that FRMD6-AS2 could interact with the 30 kb upstream beyond FRMD6 and facilitate the chromatin looping towards the promoter region of FRMD6 to enhance the expression of FRMD6. |
| Pubmed ID | 31917993 |
| Year | 2020 |
| Title | The Tumor Suppressive Effect of Long Non-Coding RNA FRMD6-AS2 in Uteri Corpus Endometrial Carcinoma |
External Links
| Links for FRMD6-AS2 | GenBank HGNC NONCODE |
| Links for uterine corpus endometrial cancer | OMIM COSMIC |