Basic Information
| LncRNA/CircRNA Name | FRlnc1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Microarray, qPCR, RNAi etc. |
| Sample | gastric cancer tissues, cell lines (MGC803, AGS, BGC823, and SGC7901) |
| Expression Pattern | up-regulated |
| Function Description | The RNA level of FRLnc1 is upregulated in 49 % (20/41) of cancer samples compared with neighboring non-cancerous stomach tissues. We also identified TGFb1 and Twist as the downstream effectors of FRLnc1 in the regulation of cell migration. Our findings suggest that FRLnc1 is involved in gastric cancer cell migration and for the first time set up the link between FOXM1 and LncRNA in cancer. |
| Pubmed ID | 25907137 |
| Year | 2015 |
| Title | A FOXM1 related long non-coding RNA contributes to gastric cancer cell migration. |
External Links
| Links for FRlnc1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |