Basic Information
| LncRNA/CircRNA Name | FOXD3-AS1 |
| Synonyms | FOXD3-AS1, pasFOXD3 |
| Region | GRCh38_1:63320884-63324441 |
| Ensemble | ENSG00000230798 |
| Refseq | NR_121634 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | glioma tissues, cell lines (U87, A172 and U251) |
| Expression Pattern | up-regulated |
| Function Description | FOXD3-AS1 was markedly up-regulated in high-grade glioma tissues (WHO grade III-IV) compared with that in low-grade glioma (WHO grade I-II) and normal brain tissues, and patients with low FOXD3-AS1 expression had grater survival probability. FOXD3-AS1 knockdown significantly inhibited cell proliferation, induced cell cycle S-phase arrest, and impaired cell migration and invasion in malignant glioma cells. As expected, we also found that the expression of FOXD3-AS1 was positively correlated with FOXD3 mRNA. Knockdown of FOXD3-AS1 reduced the protein level of FOXD3 in cultured U251 and A172 cell lines. |
| Pubmed ID | 27829996 |
| Year | 2016 |
| Title | Down-regulation of long non-coding RNA FOXD3 antisense RNA 1 (FOXD3-AS1) inhibits cell proliferation, migration, and invasion in malignant glioma cells. |
External Links
| Links for FOXD3-AS1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |