Basic Information
| LncRNA/CircRNA Name | FOXD3-AS1 |
| Synonyms | Forkhead box D3 antisense RNA 1 |
| Region | GRCh38_1:63320884-63324441 |
| Ensemble | ENSG00000230798 |
| Refseq | NR_121634 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qRT-PCR, Western blot analysis, Luciferase reporter assay |
| Sample | tumor tissues,Thyroid cancer cell lines FTC-133, SW579,TPC-1, 8505C and immortalized normal follicular epithelial cell line Nthy-ori 3-1 |
| Expression Pattern | up-regulated |
| Function Description | the expression of lncRNA FOXD3-AS1was upregulated and it had negative correlation with the level of miR-296-5p in thyroid cancer tissues and cells. LncRNA FOXD3-AS1 knockdown effectively suppressed cell proliferation and cell invasion in vitro. Further study revealed that miR-296-5p was a target of lncRNA FOXD3-AS1 and FOXD3-AS1 exerted anti-tumor effect through up-regulating miR-296-5p. Moreover, we found that FOXD3-AS1 knockdown suppressed the aggressive biological behaviors of thyroid cancer through inactivating the TGF-?1/Smads signaling pathway. |
| Pubmed ID | 31678422 |
| Year | 2020 |
| Title | Inhibition of LncRNA FOXD3-AS1 Suppresses the Aggressive Biological Behaviors of Thyroid Cancer via Elevating miR-296-5p and Inactivating TGF-?1/Smads Signaling Pathway |
External Links
| Links for FOXD3-AS1 | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |