Basic Information
| LncRNA/CircRNA Name | FOXD3-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:63320884-63324441 |
| Ensemble | ENSG00000230798 |
| Refseq | NR_121634 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, luciferase reporter assay etc |
| Sample | lung cancer tissues,cell lines(SPC-A1,H1299, A549, NHBE) |
| Expression Pattern | up-regulated |
| Function Description | FOXD3-AS1 interacted with miR-127-3p by acting as a competing endogenous RNA to suppress miR-127-3p expression, while miR-127-3p repressed MED28 expression by targeting MED28 3' untranslated region in NSCLC cells. Mechanistically, the oncogenic effects of FOXD3-AS1 overexpression were significantly attenuated by miR-127-3p overexpression and MED28 knockdown in NSCLC cells. In the xenograft mice model, FOXD3-AS1 knockdown suppressed in vivo tumor growth of A549 cells, and also up-regulated miR-127-3p expression and repressed MED28 expression in the xenograft tumors. In the clinical aspect, the downregulation of miR-127-3p and up-regulation of MED28 were respectively detected in lung cancer tissues. |
| Pubmed ID | 32196603 |
| Year | 2020 |
| Title | Highly Expressed lncRNA FOXD3-AS1 Promotes Non-Small Cell Lung Cancer Progression via Regulating miR-127-3p/mediator Complex Subunit 28 Axis |
External Links
| Links for FOXD3-AS1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |