Basic Information
| LncRNA/CircRNA Name | FOXD3-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:63320884-63324441 |
| Ensemble | ENSG00000230798 |
| Refseq | NR_121634 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | RT-qPCR, Western blot, Microarray |
| Sample | NPC tissues, cell lines (5-8F, CNE1,C666-1 and HONE-1) |
| Expression Pattern | up-regulated |
| Function Description | silencing of FOXD3-AS1 down-regulated RCN1 by competitively binding to let-7e-5p, ultimately promoting endoplasmic reticulum stress-induced apoptosis in NPC. |
| Pubmed ID | 32073875 |
| Year | 2020 |
| Title | Downregulated long non-coding RNA FOXD3-AS1 promotes endoplasmic reticulum stress-induced apoptosis by inhibiting RCN1 via let-7e-5p in nasopharyngeal carcinoma |
External Links
| Links for FOXD3-AS1 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |