Basic Information
| LncRNA/CircRNA Name | FOXD2-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:47432133-47434641 |
| Ensemble | ENSG00000237424 |
| Refseq | NR_026878 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, etc. |
| Sample | Nontumor adjacent tissues (normal nasopharynx epithelial tissues), Human astrocytes (HA-1800) and glioma cell lines (U87 and U251),Human embryonic kidney (HEK-293T) cells |
| Expression Pattern | up-regulated |
| Function Description | FOXD2 AS1 was upregulated in glioma tissue, cells, and sphere subpopulation. Upregulation of FOXD2 AS1 was correlated with poor prognosis of glioma. Downregulation of FOXD2 AS1 decreased cell proliferation, migration, invasion, stemness, and epithelial mesenchymal transition (EMT) in glioma cells and inhibited tumor growth in transplanted tumor. We also revealed that FOXD2 AS1 was mainly located in cytoplasm and microRNA (miR) 185 5p both targeted FOXD2 AS1 and CCND2 messenger RNA (mRNA) 3 untranslated region (3 UTR). miR 185 5p was downregulated in glioma tissue, cells, and sphere subpopulation. Downregulation of miR 185 5p was closely correlated with poor prognosis of glioma patients. In addition, miR 185 5p mimics decreased cell proliferation, migration, invasion, stemness, and EMT in glioma cells. CCND2 was upregulated in glioma tissue, cells, and sphere subpopulation. Upregulation of CCND2 was closely correlated with poor prognosis of glioma patients. CCND2 knockdown decreased cell proliferation, migration, invasion, and EMT in glioma cells. In glioma tissues, CCND2 expression was negatively associated with miR 185 5p, but positively correlated with FOXD2 AS1. FOXD2 AS1 knockdown and miR 185 5p mimics decreased CCND2 expression. Inhibition of miR 185 5p suppressed FOXD2 AS1 knockdown induced decrease of CCND2 expression. Overexpression of CCND2 suppressed FOXD2 AS1 knockdown induced inhibition of glioma malignancy. |
| Pubmed ID | 30520141 |
| Year | 2018 |
| Title | Long noncoding RNA FOXD2 AS1 promotes glioma malignancy and tumorigenesis via targeting miR 185 5p/CCND2 axis |
External Links
| Links for FOXD2-AS1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |