Basic Information
| LncRNA/CircRNA Name | FOXD2-AS1 |
| Synonyms | FOXC2-AS1, ODRUL |
| Region | GRCh38_1:47432133-47434641 |
| Ensemble | ENSG00000237424 |
| Refseq | NR_026878 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP, RNAi, other |
| Sample | HCC tissues and cell lines (Hep3B, MHCC97-L, MHCC97-H, SK-HEP1, HCCLM3) |
| Expression Pattern | up-regulated |
| Function Description | FOXD2-AS1 was found to be overexpressed in HCC tissues, and FOXD2-AS1 overexpression resulted in significantly shortened patient survival. FOXD2-AS1 overexpression enhanced the viability and metastasis of HCC cells in vitro and in vivo, as revealed by MTT, wound healing and cell migration assays. In addition, mechanistic studies revealed that FOXD2-AS1 upregulated the expression of the miR-206 target gene annexin A2 (ANXA2) by acting as a miR-206 sponge. |
| Pubmed ID | 30272362 |
| Year | 2018 |
| Title | Long Non-Coding RNA FOXD2-AS1 Plays an Oncogenic Role in Hepatocellular Carcinoma by Targeting miR-206 |
External Links
| Links for FOXD2-AS1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |