Basic Information
| LncRNA/CircRNA Name | FOXD2-AS1 |
| Synonyms | FOXC2-AS1, ODRUL |
| Region | GRCh38_1:47432133-47434641 |
| Ensemble | ENSG00000237424 |
| Refseq | NR_026878 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cutaneous melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, other |
| Sample | cutaneous melanoma tissues and cell lines (A2058,A-375, SK-MEL-2, and MeWo) |
| Expression Pattern | up-regulated |
| Function Description | The results of loss-of-function study showed that inhibition of FOXD2-AS1 suppresses cutaneous melanoma cell proliferation, migration and invasion through regulating phospho-Akt expression. In conclusion, FOXD2-AS1 is associated with clinical progression in cutaneous melanoma patients, and functions as oncogenic lncRNA in cutaneous melanoma cells. |
| Pubmed ID | 30426532 |
| Year | 2019 |
| Title | FOXD2-AS1 Correlates With the Malignant Status and Regulates Cell Proliferation, Migration, and Invasion in Cutaneous Melanoma |
External Links
| Links for FOXD2-AS1 | GenBank HGNC NONCODE |
| Links for cutaneous melanoma | OMIM COSMIC |